Expression of E-cadherin in Human Bladder Transitional Cell Carcinoma

Objective To investigate the clinical significance of E-cadherin (E-CD) and E-CD mRNA expression in the tissues of bladder transitional cell carcinoma (TCC). Methods 102 specimens of bladder transitional cell carcinoma and 10 specimens of normal tissues of human bladder were stained immunohistochemically with anti-Ecadherin monoclonal antibody; 24 specimens of bladder TCC and 16 specimens of normal tissue of human bladder mucosa were measured by the means of RT -PCR. All the results were analyzed statistically. Results The expressions of E-cadherin in bladder TCC correlated well with grade, stage and recurrence of the tumor, but had no significant correlation with the magnitude and number of the tumors. Conclusion Expression of E-cadherin in the tissue of TCC was closely associated with the biological behaviors of bladder TCC, which may aid early detection and prediction of the clinical course of this disease.